Title: Kinomics

N. Srinivasan*, Anamika, N. Rekha & A. Krupa

 Molecular Biophysics Unit

Indian Institute of Science

Bangalore 560012

India

*E-mail: ns@mbu.iisc.ernet.in

Ser/Thr/Tyr protein kinases are known to be involved in several signal transduction pathways in various organisms. This family of proteins is also one of the largest domain families in many eukaryotes. Phosphorylation by protein kinases is regulated by a variety of means in different kinds of kinases such as binding of a second messenger, binding of a regulatory domain/subunit and phosphorylation within and outside kinase domains.

Recognition, classification and domain structures of protein kinases encoded in the genomes of several eukaryotic and prokaryotic organisms will be presented. Recognition and classification of kinases from sequences is performed using sequence searches as well as by an understanding of structural basis of stabilization of kinase structures by key residues. Examples of newly discovered kinases will be reported. Prediction of functional properties of kinases and their potential modes of regulation derived on the basis of domain structures will be discussed. Many examples of unusual domain combinations in multi-domain kinases in bacteria, A. thaliana, O. sativa and protozoa such as Plasmodium falciparum will be reported.

A. Krupa & N. Srinivasan (2002) Prot. Sci. 11, 1580-1584.

A. Krupa & N. Srinivasan (2002) Genome Biol. 3, 66.

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A. Krupa, K.R. Abhinandan & N. Srinivasan (2004) Nucl. Acids Res. 32, 153-155.

A. Krupa, G. Preethi & N. Srinivasan (2004) J. Mol. Biol. 339, 1025-1039.

Anamika, N. Srinivasan & A. Krupa (2005) Proteins 58, 180-189.

A. Krupa & N. Srinivasan (2005) BMC Genomics  6, 129.

A. Krupa, Anamika & N. Srinivasan (2006) Gene 318, 1-13.

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