N. Srinivasan*, Anamika, N. Rekha & A. Krupa
Molecular Biophysics Unit
Indian Institute of Science
Ser/Thr/Tyr protein kinases are known to be involved in
several signal transduction pathways in various organisms. This family of
proteins is also one of the largest domain families in many eukaryotes.
Phosphorylation by protein kinases is regulated by a variety of means in
different kinds of kinases such as binding of a second messenger, binding of a
regulatory domain/subunit and phosphorylation within and outside kinase domains.
Recognition, classification and domain structures of
protein kinases encoded in the genomes of several eukaryotic and prokaryotic
organisms will be presented. Recognition and classification of kinases from
sequences is performed using sequence searches as well as by an understanding of
structural basis of stabilization of kinase structures by key residues. Examples
of newly discovered kinases will be reported. Prediction of functional
properties of kinases and their potential modes of regulation derived on the
basis of domain structures will be discussed. Many examples of unusual domain
combinations in multi-domain kinases in bacteria, A. thaliana, O. sativa and
protozoa such as Plasmodium falciparum will be reported.
A. Krupa & N. Srinivasan (2002) Prot. Sci. 11, 1580-1584.
A. Krupa & N. Srinivasan (2002) Genome Biol. 3, 66.
N. Rekha & N. Srinivasan (2003) BMC Strl. Biol. 3, 4.
A. Krupa, K.R. Abhinandan & N. Srinivasan (2004) Nucl. Acids Res. 32, 153-155.
A. Krupa, G. Preethi & N. Srinivasan (2004) J. Mol. Biol. 339, 1025-1039.
Anamika, N. Srinivasan & A. Krupa (2005) Proteins 58, 180-189.
A. Krupa & N. Srinivasan (2005) BMC Genomics 6, 129.
A. Krupa, Anamika & N. Srinivasan (2006) Gene 318, 1-13.'.$link.'';}?>